Pubmed Publications

• Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria. Vercauteren K, Gleyzer N, Scarpulla RC The Journal of biological chemistry 2009 Jan 23; 284(4):2307-19 PMID: 19036724
• PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression. Vercauteren K, Gleyzer N, Scarpulla RC The Journal of biological chemistry 2008 May 2; 283(18):12102-11 PMID: 18343819
• Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Scarpulla RC Physiological reviews 2008 Apr; 88(2):611-38 PMID: 18391175
• PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth. Vercauteren K, Pasko RA, Gleyzer N, Marino VM, Scarpulla RC Molecular and cellular biology 2006 Oct; 26(20):7409-19 PMID: 16908542
• Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Scarpulla RC Annals of the New York Academy of Sciences 2008 Dec; 1147:321-34 PMID: 19076454
• Nuclear control of respiratory gene expression in mammalian cells. Scarpulla RC Journal of cellular biochemistry 2006 Mar 1; 97(4):673-83 PMID: 16329141
• Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Brunelle JK, Bell EL, Quesada NM, Vercauteren K, Tiranti V, Zeviani M, Scarpulla RC, Chandel NS Cell metabolism 2005 Jun; 1(6):409-14 PMID: 16054090
• Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. Gleyzer N, Vercauteren K, Scarpulla RC Molecular and cellular biology 2005 Feb; 25(4):1354-66 PMID: 15684387
• Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Scarpulla RC Biochimica et biophysica acta 2002 Jun 7; 1576(1-2):1-14 PMID: 12031478
• Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells. Scarpulla RC Gene 2002 Mar 6; 286(1):81-9 PMID: 11943463
• Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. Andersson U, Scarpulla RC Molecular and cellular biology 2001 Jun; 21(11):3738-49 PMID: 11340167
• Mitochondrial DNA instability and peri-implantation lethality associated with targeted disruption of nuclear respiratory factor 1 in mice. Huo L, Scarpulla RC Molecular and cellular biology 2001 Jan; 21(2):644-54 PMID: 11134350
• Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila. Herzig RP, Andersson U, Scarpulla RC Journal of cell science 2000 Dec; 113 Pt 23:4263-73 PMID: 11069771
• cAMP-dependent phosphorylation of the nuclear encoded 18-kDa (IP) subunit of respiratory complex I and activation of the complex in serum-starved mouse fibroblast cultures. Scacco S, Vergari R, Scarpulla RC, Technikova-Dobrova Z, Sardanelli A, Lambo R, Lorusso V, Papa S The Journal of biological chemistry 2000 Jun 9; 275(23):17578-82 PMID: 10747996
• Sequential serum-dependent activation of CREB and NRF-1 leads to enhanced mitochondrial respiration through the induction of cytochrome c. Herzig RP, Scacco S, Scarpulla RC The Journal of biological chemistry 2000 Apr 28; 275(17):13134-41 PMID: 10777619
• Multiple 5'-untranslated exons in the nuclear respiratory factor 1 gene span 47 kb and contribute to transcript heterogeneity and translational efficiency. Huo L, Scarpulla RC Gene 1999 Jun 11; 233(1-2):213-24 PMID: 10375638
• Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding. Gugneja S, Scarpulla RC The Journal of biological chemistry 1997 Jul 25; 272(30):18732-9 PMID: 9228045
• Nuclear control of respiratory chain expression in mammalian cells. Scarpulla RC Journal of bioenergetics and biomembranes 1997 Apr; 29(2):109-19 PMID: 9239537
• Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription. Gugneja S, Virbasius CM, Scarpulla RC Molecular and cellular biology 1996 Oct; 16(10):5708-16 PMID: 8816484
• Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1. Gopalakrishnan L, Scarpulla RC The Journal of biological chemistry 1995 Jul 28; 270(30):18019-25 PMID: 7629110
• Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. Gugneja S, Virbasius JV, Scarpulla RC Molecular and cellular biology 1995 Jan; 15(1):102-11 PMID: 7799916
• Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Virbasius JV, Scarpulla RC Proceedings of the National Academy of Sciences of the United States of America 1994 Feb 15; 91(4):1309-13 PMID: 8108407
• Differential regulation of respiratory chain subunits by a CREB-dependent signal transduction pathway. Role of cyclic AMP in cytochrome c and COXIV gene expression. Gopalakrishnan L, Scarpulla RC The Journal of biological chemistry 1994 Jan 7; 269(1):105-13 PMID: 8276781
• NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Virbasius CA, Virbasius JV, Scarpulla RC Genes & development 1993 Dec; 7(12A):2431-45 PMID: 8253388
• Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. Virbasius JV, Virbasius CA, Scarpulla RC Genes & development 1993 Mar; 7(3):380-92 PMID: 8383622
• Nuclear respiratory factor 1 activation sites in genes encoding the gamma-subunit of ATP synthase, eukaryotic initiation factor 2 alpha, and tyrosine aminotransferase. Specific interaction of purified NRF-1 with multiple target genes. Chau CM, Evans MJ, Scarpulla RC The Journal of biological chemistry 1992 Apr 5; 267(10):6999-7006 PMID: 1348057
• Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene. Virbasius JV, Scarpulla RC Molecular and cellular biology 1991 Nov; 11(11):5631-8 PMID: 1656236
• The rat cytochrome c oxidase subunit IV gene family: tissue-specific and hormonal differences in subunit IV and cytochrome c mRNA expression. Virbasius JV, Scarpulla RC Nucleic acids research 1990 Nov 25; 18(22):6581-6 PMID: 2174541
• Mitochondrial targeting of yeast apoiso-1-cytochrome c is mediated through functionally independent structural domains. Nye SH, Scarpulla RC Molecular and cellular biology 1990 Nov; 10(11):5763-71 PMID: 2172785
• In vivo expression and mitochondrial targeting of yeast apoiso-1-cytochrome c fusion proteins. Nye SH, Scarpulla RC Molecular and cellular biology 1990 Nov; 10(11):5753-62 PMID: 2172784
• NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells. Evans MJ, Scarpulla RC Genes & development 1990 Jun; 4(6):1023-34 PMID: 2166701
• Introns in the 3'-untranslated region can inhibit chimeric CAT and beta-galactosidase gene expression. Evans MJ, Scarpulla RC Gene 1989 Dec 7; 84(1):135-42 PMID: 2514122
• Interaction of nuclear factors with multiple sites in the somatic cytochrome c promoter. Characterization of upstream NRF-1, ATF, and intron Sp1 recognition sequences. Evans MJ, Scarpulla RC The Journal of biological chemistry 1989 Aug 25; 264(24):14361-8 PMID: 2547796
• The human somatic cytochrome c gene: two classes of processed pseudogenes demarcate a period of rapid molecular evolution. Evans MJ, Scarpulla RC Proceedings of the National Academy of Sciences of the United States of America 1988 Dec; 85(24):9625-9 PMID: 2849112
• Structure and expression of rodent genes encoding the testis-specific cytochrome c. Differences in gene structure and evolution between somatic and testicular variants. Virbasius JV, Scarpulla RC The Journal of biological chemistry 1988 May 15; 263(14):6791-6 PMID: 2834389
• Both upstream and intron sequence elements are required for elevated expression of the rat somatic cytochrome c gene in COS-1 cells. Evans MJ, Scarpulla RC Molecular and cellular biology 1988 Jan; 8(1):35-41 PMID: 2827005