Summary
Dr. Elizabeth H. Blackburn, Morris Herzstein Professor in Biology and Physiology in the Department of Biochemistry and Biophysics at the University of California, San Francisco, is a leader in the area of telomere and telomerase research. She discovered the molecular nature of telomeres - the ends of eukaryotic chromosomes that serve as protective caps essential for preserving the genetic information - and the ribonucleoprotein enzyme, telomerase. Blackburn and her research team at the University of California, San Francisco are working with various cells including human cells, with the goal of understanding telomerase and telomere biology. Blackburn earned her B.Sc. (1970) and M.Sc. (1972) degrees from the University of Melbourne in Australia, and her Ph.D. (1975) from the University of Cambridge in England. She did her postdoctoral work in Molecular and Cellular Biology from 1975 to 1977 at Yale. In 1978, Blackburn joined the faculty at the University of California at Berkeley in the Department of Molecular Biology. In 1990, she joined the Department of Microbiology and Immunology at UC San Francisco, where she served as Department Chair from 1993 to 1999. Blackburn is currently a faculty member in Department of Biochemistry and Biophysics at UCSF. She is also a Non-Resident Fellow of the Salk Institute. Throughout her career, Blackburn has been honored by her peers as the recipient of many prestigious awards. She was elected President of the American Society for Cell Biology for the year 1998. Blackburn is an elected Fellow of the American Academy of Arts and Sciences (1991), the Royal Society of London (1992), the American Academy of Microbiology (1993), and the American Association for the Advancement of Science (2000). She was elected Foreign Associate of the National Academy of Sciences in 1993, and was elected as a Member of the Institute of Medicine in 2000. She was awarded the Albert Lasker Medical Research Award in Basic Medical Research (2006). In 2007 she was named one of TIME Magazine’s 100 Most influential People and she was the 2008 North American Laureate for L’Oreal-UNESCO For Women in Science. In 2009, Dr. Blackburn was awarded the Nobel Prize in Physiology or Medicine.
Dr. Elizabeth H. Blackburn, Morris Herzstein Professor in Biology and Physiology in the Department of Biochemistry and Biophysics at the University of California, San Francisco, is a leader in the area of telomere and telomerase research. She discovered the molecular nature of telomeres - the ends of eukaryotic chromosomes that serve as protective caps essential for preserving the genetic information - and the ribonucleoprotein enzyme, telomerase. Blackburn and her research team at the University of California, San Francisco are working with various cells including human cells, with the goal of understanding telomerase and telomere biology. Blackburn earned her B.Sc. (1970) and M.Sc. (1972) degrees from the University of Melbourne in Australia, and her Ph.D. (1975) from the University of Cambridge in England. She did her postdoctoral work in Molecular and Cellular Biology from 1975 to 1977 at Yale. In 1978, Blackburn joined the faculty at the University of California at Berkeley in the Department of Molecular Biology. In 1990, she joined the Department of Microbiology and Immunology at UC San Francisco, where she served as Department Chair from 1993 to 1999. Blackburn is currently a faculty member in Department of Biochemistry and Biophysics at UCSF. She is also a Non-Resident Fellow of the Salk Institute. Throughout her career, Blackburn has been honored by her peers as the recipient of many prestigious awards. She was elected President of the American Society for Cell Biology for the year 1998. Blackburn is an elected Fellow of the American Academy of Arts and Sciences (1991), the Royal Society of London (1992), the American Academy of Microbiology (1993), and the American Association for the Advancement of Science (2000). She was elected Foreign Associate of the National Academy of Sciences in 1993, and was elected as a Member of the Institute of Medicine in 2000. She was awarded the Albert Lasker Medical Research Award in Basic Medical Research (2006). In 2007 she was named one of TIME Magazine’s 100 Most influential People and she was the 2008 North American Laureate for L’Oreal-UNESCO For Women in Science. In 2009, Dr. Blackburn was awarded the Nobel Prize in Physiology or Medicine.
Current Institution | University of California, San Francisco |
Department | Department of Biochemistry and Biophysics |
Disciplines | |
Address | Department of Biochemistry and Biophysics, 600 16th Street, MC 2200, Room S312F, Genentech Hall, Mission Bay Campus San Francisco California 94158-2517 United States Phone: 415-476-4912 |
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University of Cambridge
Ph.D.,
Molecular Biology
(1975)
University of Melbourne
M.Sc.,
Biochemistry
(1972)
Publication Summary
Publications:
Papers published in refereed scientific journals
- Davidson, B.E., E.H. Blackburn and T.A.A. Dopheide. Chorismate mutase-prephenate dehydratase from Escherichia coli K-12. I. Purification, molecular weight, and amino acid composition. J. Biol. Chem. 241: 4441–4446 (1972).
- Blackburn, E.H. and F.J. R. Hird. Metabolism of glutamine and glutamate by rat liver mitochondria. Arch. Biochem. Biophys. 152: 258–264 (1972).
- Blackburn, E.H., F.J.R. Hird and I.K. Jones. Metabolism of glutamine and ammonia in rat liver: the effects of N-acetylglutamate and phosphate. Arch. Biochem. Biophys. 152: 265–271 (1972).
- E.H. Blackburn. Transcription by Escherichia coli RNA polymerase of a single-stranded fragment by bacteriophage 174 DNA 48 residues in length. J. Mol. Biol. 93: 367–374 (1975).
- Air, G.A., E.H. Blackburn, F. Sanger and A.R. Coulson. The nucleotide and amino acid sequences of the N (5') terminal region of gene G of bacteriophage φX174. J. Mol. Biol. 96: 703–719 (1975).
- E.H. Blackburn. Transcription and sequence analysis of a fragment of bacteriophage 174 DNA. J. Mol. Biol. 107: 417–431 (1976).
- Air, G.M., E.H. Blackburn, A.R. Coulson, F. Gailbert, F. Sanger, J.W. Sedat and E.B. Ziff. Gene F. of bacteriophage φX174. Correlation of nucleotide sequences from the DNA and amino acid sequences from the gene product. J. Mol. Biol. 107: 445–458 (1976).
- Blackburn, E.H. and J.C. Gall. A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. J. Mol. Biol. 120: 33–53 (1978).
- Pan, W.-C. and E.H. Blackburn. Single extrachromosomal ribosomal RNA gene copies are synthesized during amplification of the rDNA in Tetrahymena. Cell 23: 459–466 (1981).
- Blackburn, E.H. and S.-S. Chiou. Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena. Proc. Natl. Acad. Sci. USA 78: 2263–2267 (1981).
- Katzen, G.M., G.M. Cann and E.H. Blackburn. Sequence-specific fragmentation of macronuclear DNA in a holotrichous ciliate. Cell 24: 313–320 (1981).
- Yao, M.-C., E.H. Blackburn and J. Gall. Tandemly repeated C-C-C-C-A-A hexanucleotide of Tetrahymena rDNA is present elsewhere in the genome and may be related to the alteration of the somatic genome. J. Cell Biol. 90: 515–520 (1981).
- Pan, W.-C., E. Orias, M. Flacks and E.H. Blackburn. Allele-specific, selective amplification of a ribosomal RNA gene in Tetrahymena thermophila. Cell 28: 596–604 (1982).
- Szostak, J.W. and E.H. Blackburn. Cloning yeast telomeres on linear plasmid vectors. Cell 29: 245–255 (1982). 28
- Blackburn, E.H., W.-C. Pan and C. Johnson. Methylation of ribosomal RNA genes in Tetrahymena thermophila Nucl. Acids Res. 11: 5131–5145 (1983).
- Blackburn, E.H. and P.B. Challoner. Identification of a telomeric DNA sequence in Trypanosoma brucei. Cell 36: 447–457 (1984).
- Shampay, J., J.W. Szostak and E.H. Blackburn. DNA sequences of telomeres maintained in yeast. Nature 310 : 154–157 (1984).
- Bruns, P., A.L. Katzen, L. Martin and E.H. Blackburn. A drug resistant mutation in the Ribosomal DNA of Tetrahymena. Proc. Natl. Acad. Sci. USA 82: 2844–2846 (1985).
- Spangler, E. and E.H. Blackburn. The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics Paromomycin and Hygromycin. J. Biol. Chem. 260: 6334–6340 (1985).
- Howard, E.A. and E.H. Blackburn. Reproducible and variable genomic rearrangements occur in the developing somatic nucleus of the ciliate Tetrahymena thermophila. Molec. Cell. Biol. 5: 2039–2050 (1985).
- Challoner, P.B., A.A. Amin, R.E. Pearlman and E.H. Blackburn. Conserved arrangements of repeated DNA sequences in the nontranscribed spacers of ciliate ribosomal RNA genes: Evidence for molecular coevolution. Nucl. Acids Res. 13: 2661–2680 (1985).
- Greider, C.W. and E.H. Blackburn. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405–413 (1985).
- Cherry, J.M. and E.H. Blackburn. The internally located telomeric sequences in the germline chromosomes of Tetrahymena are at the conserved ends of a family of DNA elements. Cell 43: 747–758 (1985).
- Budarf, M.L. and E.H. Blackburn. Chromatin structure of the telomeric region and 3' nontranscribed spacer of Tetrahymena ribosomal RNA genes. J. Biol. Chem. 261: 363–369 (1986).
- rCehpaelaltosn oefr ,c Pil.iBat.e a mnda cEr.oHn.u Bclleaacrk briubrons.o Cmoanls RerNvAat igoenn oef mseoqleuceunlceess. aNdujaccl.e Antc tiod st hRee tse. l1o4m: e6r2ic9 9C–46A321 1 (1986).
- Larson D.D., E.H. Blackburn, P.C. Yaeger and E. Orias. Control of rDNA Replication in Tetrahymena involves a cis-Acting Upstream Repeat of a Promoter Element. Cell 47: 229–240 (1986).
- Budarf, M.L. and E.H. Blackburn. S1 Nuclease sensitivity of a double-stranded telomeric DNA sequence. Nucl. Acids Res. 15: 6273–6292 (1987).
- Larson, D.D., E.A. Spangler and E.H. Blackburn. Dynamics of telomere length variation in Tetrahymena thermophila. Cell 50: 477–483 (1987).
- Greider, C.W. and E.H. Blackburn. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two distinct primer specificity components. Cell 51: 887–898 (1987).
- Henderson, E., C.C. Hardin, Steven K. Wolk, I. Tinoco, Jr. and E.H. Blackburn. Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base parts. Cell 51: 899–908 (1987). 29
- Forney, J., E.R. Henderson and E.H. Blackburn. Identification of the telomeric sequence of the acellular slime molds Didyminum iridis and Physarum polycephalum. Nucl. Acids Res. 15: 9143– 9152 (1987).
- Forney, J.D. and E.H. Blackburn. Developmentally controlled telomere addition in wild type and mutant paramecia. Mol. Cell. Biol. 8: 251–258 (1988).
- Shampay, J. and E.H. Blackburn. Generation of telomere length heterogeneity in S. cerevisiae. Proc. Natl. Acad. Sci. USA 85: 534–538 (1988).
- E. Orias, D. Larson, Y.-F. Hu, G.-L Yu, J. Karttunen, A. Løvlie, B. Haller and E.H. Blackburn. Replacement of the macronuclear ribosomal RNA genes of a mutant Tetrahymena using electroporation. Gene 70: 295–301 (1988).
- Spangler, E.A., T. Ryan and E.H. Blackburn. Developmentally regulated telomere addition in Tetrahymena thermophila . Nucl. Acids Res. 16: 5569–5585 (1988).
- Yu, G.-L., M. Hasson and E.H. Blackburn. Circular ribosomal DNA plasmids transform Tetrahymena thermophila by homologous recombination with endogenous macronuclear ribosomal DNA. Proc. Natl. Acad. Sci. USA 85: 5151–5155 (1988).
- Henderson, E.R. and E.H. Blackburn. An Overhanging 3' terminus is a conserved feature of telomeres. Mol. Cell. Biol. 9: 345–348 (1989).
- Greider, C.W. and E.H. Blackburn. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331–337 (1989).
- Yaeger, P.C., E. Orias, W.-L. Shaiu, D.D. Larson and E.H. Blackburn. The replication advantage of a free linear rRNA gene is restored by somatic recombination in Tetrahymena thermophila. Mol. Cell. Biol. 9: 452–460 (1989).
- Shippen-Lentz, D. and E. H. Blackburn. Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers. Mol. Cell. Biol. 9: 2761–2764 (1989).
- Shampay, J. and E.H Blackburn. Tetrahymena micronuclear sequences that function as telomeres in yeast. Nucl. Acids Res. 17: 3247–3260 (1989).
- Phan, H.L., J. Forney and E.H. Blackburn. Analysis of Paramecium macronuclear DNA using pulsed field gel electrophoresis. J. Protozoology 36: 402–408 (1989).
- Robinson, E.K., P.D. Cohen and E.H. Blackburn. A novel DNA deletion-ligation reaction catalyzed in vitro by a developmentally controlled activity from Tetrahymena cells. Cell 58: 887– 900 (1989).
- Yu, G.-L. and E.H. Blackburn. Transformation of Tetrahymena thermophila with a mutated circular ribosomal DNA plasmid vector. Proc. Natl. Acad. Sci. USA 86: 8487–8491 (1989).
- Blackburn, E.H., C.W. Greider, E. Henderson, M.S. Lee, J. Shampay, and D.-Shippen-Lentz. Recognition and elongation of telomeres by telomerase. Genome 31: 553–560 (1989).
- Shippen-Lentz, D. and E. H. Blackburn. Functional evidence for an RNA template in telomerase. Science 247: 546–552 (1990).
- Yu, G.-L., J.D. Bradley, L.D. Attardi and E.H. Blackburn. In vivo alteration of telomere sequences 30 and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344: 126–132 (1990).
- Blackburn, E.H. and V. Lundblad. RNA-dependent polymerase motifs in the EST1 protein: tentative identification of a component of an essential yeast telomerase. Cell 60: 529–530 (1990).
- Yu, G.-L. and E.H. Blackburn. Amplification of tandemly repeated origin control sequences confers a replication advantage on rDNA replicons in Tetrahymena thermophila. Mol. Cell. Biol. 10: 2070–2080 (1990).
- Romero, D. and E.H. Blackburn. A conserved secondary structure for telomerase RNA. Cell 67: 343–353 (1991).
- Yu, G-L. and E.H. Blackburn. Developmentally programmed chromosome healing by telomerase in Tetrahymena. Cell 67: 823–832 (1991).
- Wyman, C. and E.H. Blackburn. Tel-1 transposon-like elements of Tetrahymena thermophila are associated with micronuclear genome rearrangements. Genetics 128: 57–67 (1991).
- Lundblad, V. and E.H. Blackburn. An alternate pathway for yeast telomere maintenance rescues est1- senescence. Cell 73: 347–360 (1993).
- Lee, M. and E.H. Blackburn. Sequence-specific DNA primer effects on telomerase polymerization activity. Mol. Cell. Biol. 13: 6586–6599 (1993).
- Shippen, D.E., E.H. Blackburn and C.M. Price. DNA bound by the Oxytricha telomere protein is accessible to telomerase and other DNA polymerases. Proc. Natl. Acad. Sci. USA 91: 405–409 (1994).
- Kapler, G.M. and E.H. Blackburn. A weak germline excision mutation blocks developmentallycontrolled amplification of the rDNA minichromosome of Tetrahymena thermophila. Genes Dev. 8: 84–95 (1994).
- Gilley, D. and E.H. Blackburn. Lack of telomere shortening during senescence in Paramecium. Proc. Natl. Acad. Sci. USA 91: 1955–1958 (1994).
- McEachern, M.J. and E.H. Blackburn. A conserved sequence motif within the exceptionally diverse telomeric sequenced of budding yeasts. Proc. Natl. Acad. Sci. USA 91: 3453–3457. (1994).
- Kapler, G.M., E. Orias and E.H. Blackburn. Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome. Genetics 137: 455–466 (1994).
- Strahl, C. and E.H. Blackburn. The effects of nucleotide analogs on telomerase and telomeres in Tetrahymena. Nuc. Acids Res. 22: 893–900. (1994)
- Bhattacharyya, A. and E.H. Blackburn. Architecture of telomerase RNA. EMBO J. 13: 5721–5731 (1994).
- Kirk, K., and E.H. Blackburn. An unusual sequence arrangement in the telomeres of the germ-line micronucleus in Tetrahymena thermophila. Genes Dev. 9: 59–71 (1995).
- Romero, D.P. and E.H. Blackburn. Circular rDNA replicons persist in Tetrahymena thermophila transformants synthesizing GGGGTC telomeric repeats. J. Eukaryotic Micro. 42: 32–43 (1995). 31
- Pan, W-J. and E.H. Blackburn. Tandem Repeats of the 5' Non-transcribed Spacer of Tetrahymena rDNA Function as high copy number autonomous replicons in the macronucleus but do not prevent rRNA gene dosage regulation. Nuc. Acids Res. 23: 1561–1569. (1995).
- Pan, W-J., R.C. Gallagher and E.H. Blackburn. Replication of an rDNA origin plasmid in the Tetrahymena macronucleus is prevented by transcription through the origin from an RNA polymerase I promoter. Mol. Cell. Biol. 15: 3372–3381 (1995).
- Cohn, M., and E.H. Blackburn. Telomerase in yeast. Science 269: 396–400 (1995).
- McEachern, M.J. and E.H. Blackburn. Runaway telomere elongation caused by telomerase RNA mutations. Nature 376: 403–409 (1995).
- Gilley, D., M.S. Lee and E.H. Blackburn. Altering specific telomerase RNA template residues affects active site function. Genes Dev. 9: 2214–2226 (1995).
- Strahl, C. and E.H. Blackburn. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol. Cell. Biol. 16: 53–65 (1996).
- Gilley, D. and E.H. Blackburn. Specific RNA residue interactions required for enzymatic functions of Tetrahymena Telomerase. Mol. Cell. Biol. 16: 66–75 (1996).
- McEachern, M.J. and E.H. Blackburn. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in K lactis lacking telomerase. Genes Dev. 10: 1822–1834 (1996).
- Krauskopf, A. and E.H. Blackburn. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383: 354–357 (1996).
- Prescott, J. and E.H. Blackburn. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal non-processivity in vivo and in vitro. Genes Dev. 11:528–540 (1997).
- Wang H. and E.H. Blackburn. De novo telomere addition by Tetrahymena telomerase in vitro. EMBO J. 16:866–879 (1997).
- Kirk, K.E., B.P. Harmon, I.K. Reichardt, J.W. Sedat and E.H. Blackburn. Block in anaphase chromosome separation caused by a telomerase template mutation. Science 275:1478–1481 (1997).
- Bhattacharyya, A. and E.H. Blackburn. Aspergillus nidulans maintains short telomeres throughout development. Nuc. Acids Res. 25:1426–1431 (1997).
- Bhattacharyya, A. and E.H. Blackburn. A functional telomerase RNA swap in vivo reveals the importance of non-template RNA domains. Proc. Natl. Acad. USA 94:2823–2827 (1997).
- Prescott, J. and E.H. Blackburn. Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev. 11:2790–2800 (1997).
- Wang, H., D. Gilley and E.H. Blackburn. A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase. EMBO J. 17:1152–1160 (1998).
- Cohn, M., M.J. McEachern and E.H. Blackburn. Telomeric sequence diversity within the genus Saccharomyces. Curr. Genetics 33:83–91 (1998).
- Gallagher, R.C. and E.H. Blackburn. A promoter region mutation affecting replication of the Tetrahymena rDNA minichromosome. Mol. Cell. Biol. 18:3021–3033 (1998). 32
- Frenck, R.W., Blackburn, E.H. and K.M. Shannon. The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl. Acad. Sci. USA, 95:5607–5610 (1998).
- Cohen, P.D. and E.H. Blackburn. Two types of telomeric chromatin in Tetrahymena thermophila. J. Mol. Biol. 280:327–344 (1998).
- Fulton, T.B. and E.H. Blackburn. Identification of Kluyveromyces lactis telomerase: discontinuous synthesis along the thirty nucleotide-long templating domain. Mol. Cell. Biol 18(9):4961–70 (1998).
- Krauskopf, A. and E.H. Blackburn. Rap1 Protein Regulates Telomere Turnover in Yeast. Proc. Natl. Acad. Sci. USA. 95(21):12486–91 (1998).
- Roy, J., Boswell Fulton, T. and E. H. Blackburn. Specific telomerase RNA residues distant from the template are essential for telomerase function. Genes Dev. 12(20): 3286–3300 (1998).
- Cano, M. I., J. Dungan, N. Agabian, and E. H. Blackburn. Telomerase in Kinetoplastid Parasitic Protozoa. Proc. Natl. Acad. Sci. USA. 96: 3616–3621 (1999).
- Zhu, J., H. Wang, J. M. Bishop, and E. H. Blackburn. Telomerase extends the lifespan of virustransformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA. 96: 3723– 3728 (1999).
- Smith, C.D. and E.H. Blackburn. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast. Journal of Cell Biology 145(2): 203–214 (1999).
- Gilley, D. and E.H. Blackburn. The telomerase RNA pseudoknot is critical for the stable assembly of the catalytically active ribonucleoprotein. Proc. Natl. Acad. Sci. USA. 96: 6621–6625 (1999).
- Hsu, H.-L., D. Gilley, E.H. Blackburn, and D.J. Chen. Ku is associated with the telomere in mammals. Proc. Natl. Acad. Sci. USA. 96: 12454–12458 (1999).
- Prescott, J. and E.H. Blackburn. Telomerase RNA Template Mutations Reveal Sequence-Specific Requirements for the Activation and Repression of Telomerase Action at Telomeres. Mol. Cell. Biol. 20: 2941-2948 (2000).
- Tzfati, Y., T.B. Fulton, J. Roy, and E.H. Blackburn. Template boundary in a yeast telomerase specified by RNA structure. Science. 288(5467):863-7 (2000).
- Ware T.L., H. Wang, and E.H. Blackburn. Three telomerases with completely non-telomeric template replacements are catalytically active. EMBO Journal 19(12): 3119-3131 (2000).
- McEachern, M.J., S. Iyer, T.B. Fulton, and E.H. Blackburn. Telomere fusions caused by mutating the terminal region of telomeric DNA. Proc. Natl. Acad. Sci. USA. 97: 11409-11414 (2000).
- Kim. M.M., M.A. Rivera, I.L. Botchkina, R. Shalaby, A.D. Thor, and E.H. Blackburn. A low threshold level of expression of mutant-template telomerase RNA is sufficient to inhibit human tumor cell growth. Proc. Natl. Acad. Sci. U.S.A. 98:7982-7987 (2001).
- Chan, S. J. Chang, J. Prescott, and E.H. Blackburn. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Current Biology 11: 1240-1250 (2001).
- Nautiyal, S., J. DeRisi, and E.H. Blackburn. A genome-wide gene-expression response to telomerase deletion mutant of S. cerevisiae. Proc. Natl. Acad Sci. U.S.A. 99 (14):9316-21 (2002). 33
- McEachern, M.J., D.H. Underwood and E.H. Blackburn. Dynamics of telomeric DNA turnover in yeast. Genetics 160: 63–73 (2002).
- Cano, M.I.N., J.J. Blake, E.H. Blackburn, and N. Agabian A trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity. J. Biol. Chem. 277:896-906 (2002).
- Seto, A.G., A.J. Livengood, Y. Tzfati, E.H. Blackburn, and T.R. Cech. A bulged stem tethers Est1p to telomerase RNA in budding yeasts. Genes Dev. 16: 2800-2812 (2002).
- Comolli, L.R., I. Smirnov, L. Xu, E.H. Blackburn and T.L. James. A molecular switch underlies a human telomerase disease. Proc. Natl. Acad Sci. U.S.A. 99: 16998-17003(2002).
- Smith, C.D., D.L. Smith, J.L. DeRisi and E.H. Blackburn. Telomeric protein distributions and remodeling through the cell cycle in S. cerevisiae. Mol. Biol. Cell 14: 556-570 (2003). (First published online in MBC in Press, December 7 2002).
- Ly, H., L. Xu, M. Rivera, T.G. Parslow and E.H. Blackburn. A role for a novel ‘trans-pseudoknot’ RNA-RNA interaction in the functional dimerization of human telomerase. Genes Dev 17: 1078- 1083 (2003).
- Chan, S. and E.H. Blackburn. Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Molec Cell 11:1379-1387 (2003).
- Tzfati, Y., Knight, Z., Roy, J. and E.H. Blackburn. A novel pseudoknot element is essential for the action of a yeast telomerase. Genes Dev 17:1779-1788 (2003).
- Kim, M.M, L. Xu and E. H. Blackburn. Catalytically normal human telomerase mutants with allele-specific biological properties. Exper Cell Res 288: 277-287 (2003).
- Ly, H., Blackburn, E.H. and Parslow, T.G. Comprehensive structure-function analysis of the core domain of human telomerase RNA. Mol Cell Biol 23: 6849-6856 (2003).
- Seto, A.G., K. Umansky, Y. Tzfati, A.J. Zaug, E.H. Blackburn, and T.R. Cech. A templateproximal RNA paired element contributes to S. cerevisiae telomerase activity. RNA. 9:1323-1332 (2003).
- Lin, J., D.L. Smith and E.H. Blackburn. Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response. Molec. Biol. Cell 15: 1623-1634 (2004) (Published online before print in MBC in Press, January 23, 2004).
- Lin, J. and E.H. Blackburn. Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev. 18: 387-396 (2004) (Published online before print, Feb. 20, 2004).
- Makovets, S., I. Herskowitz and E.H. Blackburn. Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Mol. Cell. Biol. 24: 4019-4031 (2004).
- Li, S., J.E. Rosenberg, A.A. Donjacour, I.L. Botchkina, Y.-K. Hom, G.R. Cunha and E.H. Blackburn. Rapid inhibition of cancer cell growth induced by lentiviral expression of mutanttemplate telomerase RNA constructs and anti-telomerase siRNA. Cancer Res 64: 4833-4840 (2004).
- Nosrati, M. S. Li, S. Bagheri, D. Ginzinger, E.H. Blackburn, R.J. Debs, and M. Kashani-Sabet. Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA. Clin 34 Cancer Res. 10:4983-4990 (2004).
- Lin, J., H. Ly, A. Hussain, M. Abraham, S. Pearl, T.G. Parslow, Y. Tzfati and E.H. Blackburn. A universal telomerase RNA core structure includes structure motifs required for binding the telomerase reverse transcriptase protein. Proc. Natl. Acad. Sci. USA 101:14713-8 (2004).
- Levy, D.L. and E.H. Blackburn. Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length. Mol. Cell. Biol. 24: 10857-10867 (2004).
- Epel, E.S., E.H. Blackburn, J. Lin, F. Dhabar, N. Adler, J. Morrow, and R. Cawthon. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA. 101: 17312-15 (2004).
- Rivera, M.A. and E.H. Blackburn. Processive utilization of the human telomerase template: Lack of a requirement for template switching. J Biol Chem 279: 53770-53781 (2004).
- Xu, L. and E.H. Blackburn. Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol 167: 819-830 (2004).
- Li, S., J. Crothers, C.M. Haqq and E.H. Blackburn. Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J. Biol. Chem. 280:23709-23717 (2005).
- Ly, H., M. Schertzer, W. Jastaniah, J. Davis, S.-L. Yong, Q. Ouyang, E.H. Blackburn, T.G. Parslow and P.M Lansdorp. Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita Blood 106: 1246- 1252 (2005). (Online May 10, 2005 [Epub ahead of print]).
- Epel, E.S., J. Lin, F.H. Wilhelm, O.M. Wolkowitz, R. Cawthon, N. Adler, C. Dolbier, W.B. Mendes, and E.H. Blackburn. Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31: 277-287 (2006) [Epub: Nov. 17, 2005].
- Goldkorn, A. and E.H. Blackburn. Assembly of mutant template telomerase RNA into catalytically active telomerase ribonucleoprotein at the telomere is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Research 66 (11):5763-71 (2006).
- Bagheri S., Nosrati M., Li S., Fong S., Torabian S., Rangel J., Moore D.H., Feerman S., Laposa R.R., Baehner F.L., Sagebiel R.W., Cleaver J.E. Haqq C., Debs R.J. Blackburn E.H. and Kashani- Sabet M. Genes and pathways downstream of telomerase in melanoma metastasis. Proc. Natl. Acad. Sci. USA 103: 11306-11311 (2006).
- Min Hsu, Michael J. McEachern, Alain T. Dandjinou, Yehuda Tzfati, Erica Orr, Elizabeth H. Blackburn, and Neal F. Lue Telomerase core components protect Candida telomeres from aberrant overhang accumulation, PNAS, 104(28):11682-7. Epub 2007 Jul 3. PMCID: PMC1913905
- Njajou OT, Cawthon RM, Damcott CM, Wu S-H, Ott S, Garant MJ, Blackburn EH, Mitchell BD, Shuldiner AR, Hsueh W-C. Telomere length is paternally inherited and is associated with parental lifespan. PNAS, 104 (29):12135-9. Epub 2007 Jul 10. PMCID: PMC1924539
- Xu, L, Blackburn, EH. Human Cancer Cells Harbor T-Stumps, a Prominent Novel Class of Extremely Short Telomeres. Molecular Cell 28 (2):315-27 (2007). PMCID: PMC2081152
- Makovets, S., Williams, T.L., and EH Blackburn. The telotype defines the telomere state in S. cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase. Genetics 78 (1):245-57 (2008). PMCID: PMC2206075 35
- Anderson, C.M., Korkin, D., Smith, D.L., Makovets, S., Seidel, J.J., Sali, A. and E.H. Blackburn. Tel2 mediates activation and localization of ATM/Tel1 kinase to sites of DNA damage. GenesDev 22 (7):854-9 (2008). PMCID: PMC2279195
- Stohr, B, E.H. Blackburn. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res. 68 (13):5309-17 (2008). PMCID: PMC2553270
- Seidel, J, Anderson, CM and E.H. Blackburn. A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response. Mol Cell Biol. 28 (18):5736-46 (2008). Epub 2008 Jul 14. PMCID: PMC2546937
- Ornish D, Lin J, Daubenmier J, Weidner G, Epel E, Kemp C, Magbanua MJ, Marlin R, Yglecias L, Carroll PR, Blackburn EH. Increased telomerase activity in a cohort undergoing comprehensive lifestyle changes. Lancet Oncol. 9 (11):1048-57 (2008). Epub 2008 Sept 15. PMID: 18799354 [PubMed-in process]
- Wang, XY, Kam, Z, Carlton, PM, Xu, L, Seday, JW and E.H. Blackburn. Rapid Telomere Motions in Live Human Cells Analyzed by Highly Time-Resolved Microscopy. Epigenetics and Chromatin 1 (1):4 (2008). Epub 2008 October 27. PMCID: PMC2585561
- Anderson, C. and E.H. Blackburn. Mec1 function in the DNA damage response does not require its interaction with Tel2. Cell Cycle. 7 (23): 3695-8 (2008). [Epub ahead of print]. PMID: 19029808 [PubMed - in process]
- Kiefer, A, Lin, J, Blackburn, E, and Epel, E. Dietary Restraint and Telomere Length in Pre- and Postmenopausal Women. Psychosomatic Medicine. Psychosom Med. 2008 70 (8):845-9. PMID: 18923062 [PubMed - indexed for MEDLINE]
- Li, S, Makovets, S, Matsuguchi, T, Blethrow, JD, Shokat, KM, and E.H. Blackburn. Cdk1- dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell. 136: 50-61 (2009). PMCID: PMC2642970.
- O’Donovan, A., Lin, J., Wolkowitz, O., Dhabhar, F.S., Tillie, J.M., Blackburn, E., and Epel, E. Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in postmenopausal women. Brain Behav Immun. 23(4):446-449. PMID: 19111922 [PubMed - in process]
- Epel, ES, Merkin, SS, Cawthon, R, Blackburn, EH, Adler, NE, Pletcher ,MJ and Seeman, TE. The Rate of Leukocyte Telomere Shortening Predicts Mortality from Cardiovascular Disease in Elderly Men. Aging. 1: 81- 88. (2009)
Invited reviews, chapters and articles
- Yao, M.-C., E. Blackburn and J.G. Gall. Amplification of the rRNA genes in Tetrahymena. Cold Spring Harbor Symp. Quant. Biol. 43: 1293–1296 (1979).
- Gall, J.G., M.-C. Yao, E.H. Blackburn, R.C. Findly and M. Wild. The extrachromosomal ribosomal DNA of Tetrahymena and Paramecium. In Specific Eukaryotic Genes, pp. 229–305, (Eds. J. Engberg, H. Klenow and V. Leick) Munksgaard, Copenhagen (1979).
- Blackburn, E.H. Characterization and species differences of rDNA: protozoans. In The Cell Nucleus, Vol. X, pp. 145–170 (Eds., H. Busch and L. Rothblum) Academic Press, New York (1982).
- Blackburn, E.H., M.L. Budarf, P.B. Challoner, J.M. Cherry, E.A. Howard, A.L. Katzen, W.-C. Pan 36 and T. Ryan. DNA termini in ciliate macronuclei. Cold Spring Harbor Symp. Quant. Biol. 47: 1195–1207 (1983).
- Blackburn, E.H. Telomeres: Do the ends justify the means? Cell 37: 7–8 (1984).
- Blackburn, E.H. and J.W. Szostak. The molecular structure of centomeres and telomeres. Ann. Rev. Biochem. 53: 163–194 (1984).
- Blackburn, E.H. Artificial chromosomes in yeast. Trends in Genetics 1: 8–12 (1985).
- Blackburn, E.H., P. Challoner, M. Cherry, E. Howard, T. Ryan and E. Spangler. Genomic rearrangements in macronuclear development of Tetrahymena. In Genome Rearrangement, UCLA Symposia on Molecular and Cellular Biology New Series, Vol. 20: 191–203 (1985).
- Blackburn, E.H. Structure and formation of telomeres in holotrichous ciliates. In Molecular approaches to the study of protozoan cells. (Ed. K.W. Jeon), Vol. 99: International Review of Cytology, pp. 29–47 (1986).
- Blackburn, E.H. Molecular structure of telomeres in lower eukaryotes. In Molecular Developmental Biology, (Ed., L. Bogorad), Alan R. Liss, Inc., New York, pp. 69–82 (1986).
- Blackburn, E.H. Telomeres. In The Molecular Biology of Ciliated Protozoa, (Editor, J.G. Gall) Academic Press, Inc., pp. 155–178 (1986).
- Blackburn, E.H. and K.M. Karrer. Genomic reorganization in ciliated protozoans. Ann. Rev. Genet. 20: 501–521 (1986).
- Blackburn, E.H., D. Larson, C. Greider, P. Challoner, E. Spangler, P. Yaeger and E. Orias. Developmentally controlled telomere formation and genomic rearrangement in Tetrahymena. Molecular Approaches to Developmental Biology, UCLA Symposia on Molecular and Cellular Biology New Series, Vol. 20, pp. 293–302 (1987).
- Blackburn, E.H. Nonchromosomal genes. Book review: In Nature, 237: pp. 307 (1987).
- Blackburn, E.H. Developmentally controlled DNA excision in ciliates. Trends in Genetics 3(9): 235–236 (1987).
- E. Henderson, D. Larson, W. Melton, J. Shampay, E. Spangler, C. Greider, T. Ryan, and E. Blackburn. Structure, synthesis, and regulation of telomeres. In Cancer Cells 6/Eukaryotic DNA Replication, Cold Spring Harbor Laboratory, Vol 6: pp. 453–461 (1988).
- Blackburn, E.H. Telomeres sans frontieres. News and Views article in Nature 343: 122 (1990).
- Blackburn, E.H. Telomeres: Structure and Synthesis. Mini-review in J. Biol. Chem. 265: 5919– 5921 (1990).
- Blackburn, E.H. Telomeres and their Synthesis. Perspective in Science, 249: 489–490 (1990).
- Blackburn, E.H. Structure and Function of telomeres. Review Article in Nature 350: 569–573 (1991).
- Blackburn, E.H. Copy editing - what's the U's? News and Views article in Nature 346: 609 (1990).
- Blackburn, E.H. Telomeres. Trends in Biochemical Sciences. 16: 378–381 (1991).
- Blackburn, E.H. Telomerases. Ann. Rev. Biochemistry. 61: 113–129 (1992). 37
- Blackburn, E.H. Telomeres and Their Synthesis. The Harvey Lectures. Series 86: pp. 1–18 (1992)
- Blackburn, E.H. Telomerases. In "Reverse Transcriptase". Editors, S. Goff and A.M. Skalka. Cold Spring Harbor Laboratory, Ch. 18 (1993).
- Blackburn, E.H. Telomerase. In " The RNA World". Editors, R.F. Gesteland and J.F. Atkins. Cold Spring Harbor Laboratory, Ch. 22 (1993).
- Lee, M.S., R.C. Gallagher, J. Bradley and E.H. Blackburn. In Vivo and In Vitro studies of telomeres and telomerase. Cold Spring Harbor Symposium on Quantitative Biology, 58: 707–718 (1993).
- Blackburn, E.H. Telomeres: No end in sight. Cell, 77:621–623 (1994).
- Blackburn, E.H. Developmentally programmed healing of chromosomes. In "Telomeres". Editors, C. Greider and E. Blackburn. Cold Spring Harbor Laboratory Press, 193–218 (1995).
- Kapler, G.M., D.L. Dobbs and E.H. Blackburn. DNA Replication in Tetrahymena. In "DNA Replication in Eukaryotic Cells". Editor, M.L. DePamphilis. Cold Spring Harbor Laboratory Press, 915–932 (1996).
- Greider, C.W. and E.H. Blackburn. E.H. Telomeres, telomerase and cancer. Scientific American 274:80–85 (1996).
- Blackburn, E., A. Bhattacharyya, D. Gilley, K. Kirk, A. Krauskopf, M. McEachern, J. Prescott and T. Ware. The telomere and telomerase: how do they interact? In “Telomeres and Telomerase” John Wiley & Sons. (Ciba Foundation Symposium 211) p.2–19 (1997).
- Blackburn, E.H. The Telomere and Telomerase: Nucleic Acid-Protein Complexes Acting in a Telomere Homeostasis System. Biochemistry (Moscow) 62:1196–1201 (1997).
- Blackburn, E.H. Telomerase RNA Structure and Function. In "RNA Structure and Function". Editors, R.W. Simons and M. Grunberg-Manago. Cold Spring Harbor Laboratory Press, 669– 693 (1998).
- Hiraoka, Y., E. Henderson and E.H. Blackburn. Not so peculiar: fission yeast telomere repeats. TIBS 23:126 (1998).
- Blackburn, E.H. Telomerase. In "The RNA World, Second Edition". Editors, R.F. Gesteland and J.F. Atkins. Cold Spring Harbor Laboratory, 609–635 (1999).
- Blackburn, E., D. Gilley, T. Ware, A. Bhattacharyya, K. Kirk and H. Wang. Studying the Telomerase RNA in Tetrahymena. In “Methods in Cell Biology: Tetrahymena thermophila”. Editors, D. Asai and J. Forney. Academic Press, 417–432 (1999).
- Blackburn, E.H. The telomere and telomerase: how do they interact? Mount Sinai Journal of Medicine. 66(5 & 6): 292–300 (1999).
- Prescott, J. and E.H. Blackburn. Telomerase: Dr. Jekyll or Mr. Hyde? Current Opinion in Genetics & Development 9: 368–373 (1999).
- Blackburn, E.H. Telomeres and telomerase. Keio Journal of Medicine 49(2): 59-65 (2000).
- McEachern, M.J., A. Krauskopf, and E.H. Blackburn. Telomeres and their control. Annual Review of Genetics. 34: 331-358 (2000). 38
- Blackburn, E.H. The end of the (DNA) line. Nature Structural Biology. 10: 847-850 (2000).
- Blackburn, E.H., S. Chan, J. Chang, T.B. Fulton, A. Krauskopf, M.J. McEachern, J. Prescott, et al. Molecular manifestations and molecular determinants of telomere capping. Cold Spring Harbor Symposia on Quantitative Biology: Biological Responses to DNA Damage. Vol. LXV 253-263 (2000).
- Blackburn, E.H. Telomere states and cell fates. Nature 408 (6808): 53-56 (2000).
- Blackburn, E.H. Switching and signaling at the telomere. Cell. 106: 661-673 (2001).
- Prescott, J. and E.H. Blackburn. Telomeres and telomerase. In Wiley Encyclopedia of Molecular Medicine. John Wiley & Sons, Inc. New York, New York. 5: 3110-3114 (2001).
- Chan, S. and E.H. Blackburn. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene 21: 553-563 (2002).
- Chan, S.R.W.L. and E.H. Blackburn. Telomeres and telomerase. Phil. Trans. R. Soc. Lond. B. 359: 109-121 (2004). (First appeared online December 1, 2003)
- Greider, C.W. and E.H. Blackburn. Tracking telomerase. Cell. S116: S83-S86 (2004).
- Blackburn, E.H. Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Letters 579:859-862 (2005).
- Blackburn, E.H. Telomerase and Cancer: Kirk A. Landon--AACR prize for basic cancer research lecture. Mol Cancer Res. 3:477-82 (2005).
- Blackburn, E.H. Cell biology: Shaggy mouse tales. Nature 436:922-923 (2005).
- Blackburn, E.H. A History of Telomere Biology. In “Telomeres, Second Edition”. Editors, T. de Lange, V. Lundblad and E.H. Blackburn. Cold Spring Harbor Laboratory Press, 1-20 (2006).
- Blackburn, E.H. A personal account of the discovery of telomerase. In "Telomeres, Second Edition". Editors, T. de Lange, V. Lundblad and E.H. Blackburn. Cold Spring Harbor Laboratory Press, 551-563 (2006).
- Blackburn, E.H., Greider, C.W., and Szostak, J.W. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nature Medicine 12:1133-1138 (2006).
- Li, S. and Blackburn, E.H. Expression and Suppression of Human Telomerase RNA. Cold Spring Harbor Symposia on Quantitative Biology. Vol. LXXI, pages 211-215. (2006).
- Lin, J, Epel, E and Blackburn EH. Telomeres and Telomerase in Human Health and Disease. Research and Perspectives in Neuroscience, Fondation Ipsen, Springer Press. (2007)
Books
Other Publications