UCLA MDCUNE Bioinformatics

William Grisham
UCLA

Course Description

This module is a completely computer-based introduction to bioinformatics resources.  This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in answering research questions.  Students integrate information gathered from a website dedicated to the mouse brain (Mouse Brain Library), Quantitative Trait Locus analysis (WebQTL from GeneNetwork), bioinformatics and gene expression analyses (UCSC Genome Browser, NCBI Entrez Gene, and Allen Brain Atlas), and an information resource (PubMed).

Instructors can use these various websites in concert to introduce bioinformatic resources, as well as to teach the following: genetics from the phenotypic level to the molecular level, aspects of neuroanatomy and histology, statistics, QTL analysis, and molecular biology (including in situ hybridization and microarray analysis).

As a result, students will: discover the region(s) of the chromosome(s) influencing the phenotypic trait, generate a list of candidate genes (narrowed by expression data, find the in situ pattern of a given gene in the region of interest, look up the nucleotide sequence of the candidate gene, and find articles describing the gene.

Video Lectures

UCLA MDCUNE Bioinformatics: Lecture 1 (Lecture 1 of 3)

on Dec 28, 2011
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UCLA MDCUNE Bioinformatics: Lecture 2 (Lecture 2 of 3)

on Dec 28, 2011
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UCLA MDCUNE Bioinformatics: Lecture 3 (Lecture 3 of 3)

on Dec 28, 2011
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